BPC-157 (Pentadecapeptide) – Research Grade
Product Overview
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from a protein naturally occurring in human gastric juice. Composed of 15 amino acids, its structure is highly stable.
In research settings, BPC-157 is primarily investigated for its potent cytoprotective properties and its unique ability to modulate the body's natural healing and tissue repair mechanisms across multiple biological systems.
The peptide is offered as a research-grade material intended solely for in vitro and animal research applications. It is not approved for human or therapeutic use.
Mechanisms of Action
Research has uncovered several key pathways through which BPC-157 exerts its therapeutic-like effects:
Mechanism
Description
Key Research Pathway
Angiogenesis Promotion
Stimulates the formation of new blood vessels, essential for wound healing and tissue regeneration.
VEGFR2 signaling
Fibroblast Activation
Enhances the proliferation and migration of fibroblasts, the primary cells responsible for synthesizing collagen and the extracellular matrix.
General cell signaling
Nitric Oxide (NO) System Modulation
Helps regulate the NO-system, balancing vasodilation and protecting endothelial integrity.
NOS-cGMP-pathway
Growth Factor Interaction
Exhibits a synergistic effect with various growth factors, potentially increasing receptor sensitivity.
Receptor-level interaction
Detailed Pathway Focus: Tissue Repair
BPC-157 is extensively studied for its accelerated healing effects on connective tissues, particularly tendons and ligaments. This is believed to be mediated by its specific interaction with the FAK-paxillin pathway, which is crucial for cell-matrix interactions and cell migration—fundamental processes in the repair of damaged tissue.
Key Research Applications
The broad spectrum of biological activity associated with BPC-157 has led to its investigation across several major fields of preclinical research:
1. Gastrointestinal Health
BPC-157 was originally discovered and named for its role in gastric protection. Research focuses on:
- Mucosal Barrier Integrity: Protecting the gastric, intestinal, and colon mucosa from various insults (e.g., NSAIDs, alcohol, stress).
- Healing: Accelerating the repair of esophageal, stomach, and duodenal lesions and fistulas.
2. Musculoskeletal System
A significant area of study is its impact on orthopedic injuries:
- Tendon and Ligament Repair: Demonstrating accelerated healing rates in animal models of Achilles tendon and patellar ligament injury.
- Bone Healing: Research indicates potential benefits in fracture repair by modulating bone morphogenetic proteins.
- Muscle Regeneration: Investigating effects on damaged muscle tissue.
3. Neuroprotection and CNS Research
BPC-157 has shown promise in studies involving the Central Nervous System (CNS):
- Drug-Induced Neurotoxicity: Investigating protective effects against damage caused by various pharmacological agents.
- Traumatic Brain Injury (TBI): Studies explore its potential to mitigate post-injury effects and promote neurological recovery.
- Dopamine System: Research suggests BPC-157 may modulate dopamine release and uptake.
4. Cardiovascular Applications
Preclinical studies indicate potential for vascular and cardiac benefit:
- Collateral Vessel Formation: Promoting the growth of collateral blood vessels in ischemic tissues, such as after vascular occlusion.
- Cardioprotection: Investigating protective actions against oxidative stress and damage in myocardial tissue.
Chemical Specifications
Parameter
Specification
Peptide Sequence
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular Formula
C62H98N16O22
Molecular Weight
1419.53 g/mol
Purity
>98% (HPLC)
Format
Lyophilized Powder
Storage & Stability Profile
Proper handling and storage are essential to maintain the integrity and bioactivity of the research-grade peptide.
Shipping & Unopened Storage
- Shipping: Stable at room temperature for up to 3–4 months.
- Long-Term Storage (Unopened Vial): -80°C (-112°F) is strongly recommended for storage exceeding 6 months. Alternatively, storage at -20°C is acceptable for shorter periods (up to 6 months).
Reconstitution and Working Solution Storage
- Reconstitution Solvent: Use sterile bacteriostatic water (0.9% NaCl with 0.9% benzyl alcohol) for reconstitution.
- Handling: Gently swirl the vial; do not shake aggressively.
- Storage (Reconstituted Solution): Store the liquid solution at (<4°C/39°F).
- Stability (Reconstituted Solution): The working solution should be used within 30 days of reconstitution to ensure maximal potency.
For further information regarding experimental protocols, please refer to the attached Technical Data Sheet: File
Disclaimer: This product is intended for in vitro laboratory research use only and is not intended for human consumption or therapeutic use. Researchers are responsible for complying with all applicable regulations regarding the handling of research materials. Any questions regarding the product's application in a research context can be directed to Person via email.